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Has pronounced sedative effect. Inhibits reverse neural hostage release noradrenaline and serotonin increases. Does not violate the motor gastro - gastrointestinal tract. Duration of action - about 4-8 hours. Distribution: Tying with plasma proteins is about 20%. Ultracet penetrates through the hematite-entsefallichesky and placental barriers. Approximately 0.1% is allocated to breast milk. Withdrawal: Ultracet and its metabolites are derived mainly kidneys (90%) and through the intestine (10%). The half, regardless of the introduction of ways, is about 6 hours. Patients in old age, with liver cirrhosis and kidney failure in half period, the value increases. Indications for use: Pain syndrome middle and strong intensity varying etiology (post-operative period, trauma, pain among cancer patients). With the aim of pain in painful diagnostic or therapeutic manipulation. Contraindications: Increased sensitivity to drugs. Dosage: Dosage determined by a doctor. Individually, depending on the intensity and nature of complaints. Side effects: The most characteristic dizziness, nausea, constipation, headache, drowsiness, vomiting, skin itching (these side effects occur at 30 - 15% of patients receiving Ultracet) Overdosage (intoxication) drug: The most dangerous consequences overdose Ultracetom are narrowing pupils, vomiting, respiratory depression and convulsions. When suspected poisoning should immediately seek medical help. Special instructions: With the increased use of time intervals Ultracet in patients older. With caution and under the supervision of a doctor should use the drug to patients with impaired renal function and liver, with craniocerebral injuries, increased intracranial pressure, epilepsy patients, as well as those with drug addiction to opioids. Expiration: Expiration of 5 years. You should not use the medicine after the expiration of the specified expiry date on the package. 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